-
Adverse outcome pathway
cell culture information with toxicity and proteomic changes. This dataset is associated with the following publication: VanEmon, J., P. Pan, and F. Van Breukelen. Effects of... -
Toward an AOP Network-based tiered testing strategy for the assessment of thy...
No novel data were reported in association with this product. This dataset is not publicly accessible because: The associated publication is a review/forum-type article. No... -
data for aromatase 3D qsar modeling
computational chemistry data (very complex; need to be an expert to understand and use. This dataset is associated with the following publication: Lee, S., and M. Barron.... -
Larval fathead minnow swim bladder inflation following exposure to 2-mercapto...
In this study, a hypothesized adverse outcome pathway (AOP) linking inhibition of thyroid peroxidase (TPO) activity to impaired swim bladder inflation was investigated in... -
Representing the Process of Inflammation as Key Events in Adverse Outcome Pat...
A set of three proposed "hub" key events were used to link together a series of example adverse outcome pathway (AOP) descriptions that were previously not linked in an AOP... -
In vivo and In vitro neurochemical-based assessments of wastewater effluents ...
All primary data reported in this paper were generated by non-federal collaborators from the University of Michigan and McGill University. US EPA-ORD personnel collected and... -
Adverse Outcome Pathway Network-Based Assessment of the Interactive Effects o...
Adverse outcome pathway (AOP) networks potentially provide a basis for predictive approaches to assess the toxicity of chemical mixtures. This study evaluated the utility of a... -
Data from "A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pime...
The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation for the three... -
Adverse outcome pathway (AOP) development and weight of evidence evaluation a...
The majority of this dataset includes the query output from online databases ECOTOX and SeqAPASS used to support the ecological AOP case studies described within the manuscript.... -
Adverse Outcome Pathway Networks I: Development and Applications
In September, 2015, a water sample was collected downstream of a major metropolitan waste water treatment plant that discharges to the South Platte River, Colorado, USA. The... -
Adverse Outcome Pathway Networks II: Network Analytics
The data set provides a set of txt files and cytoscape files that were used to construct the example AOP networks included in the paper. Additionally, a supplementary table file... -
An Integrated Approach for Identifying Priority Contaminant in the Great Lake...
Prioritization of chemicals was performed on two Areas of Concerns in the Great Lakes An integrated risk surveillance and monitoring approach was applied Bio-effect prediction... -
Prior knowledge-based approach for associating contaminants with biological e...
Concentrations of 127 organic chemicals measured in water samples collected from five locations in proximity to two municipal wastewater treatment plants in the St. Croix River... -
Effects of the antimicrobial contaminant triclocarban, and co-exposure with t...
Triclocarban (TCC) is a widely used antimicrobial agent that is routinely detected in surface waters. The present study was designed to examine TCC’s efficacy and mode of action... -
Derivation and Evaluation of Putative Adverse Outcome Pathways for Effects of...
Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme activity in... -
Fathead minnow whole-mount in situ hybridization (WISH)
This study demonstrates the potential of whole-mount in situ hybridization (WISH), in conjunction with quantitative real-time polymerase chain reaction (QPCR) assays, to examine...