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(REPRODUCTIVE TOXICOLOGY) EMBRYONIC VASCULAR DISRUPTION ADVERSE OUTCOMES: LI...
This study evaluated two anti-angiogenic agents, 5HPP-33 and TNP-470, across the ToxCastDB HTS assay platform and anchored the results to complex in vitro functional assays: the... -
(ALTEX) Use of High-throughput in vitro toxicity screening data in cancer haz...
Three recent IARC Working Groups pioneered inclusion of the US Environmental Protection Agency (EPA) ToxCast program high-throughput screening (HTS) data to supplement other... -
Quantitative Structure-Use Relationship Model thresholds for Model Validation...
This file contains value of the model training set confusion matrix, domain of applicability evaluation based on training set to predicted chemicals structural similarity, and... -
Chemical Exposure Pathway Prediction for Screening and Priority-Setting
We created a consensus, meta-model using the Systematic Empirical Evaluation of Models framework in which the predictors of exposure were combined by pathway and weighted... -
Confirmation of High-Throughput screening data and novel mechanistic insights...
All data is generated by the external authors or taken from public data sources. This dataset is not publicly accessible because: Data was not collected in EPA labs or paid for... -
(Toxicology) Identifying Environmental Chemicals as Agonists of the Androgen ...
The paper has data generated by NIH and the EPA coauthors provided input into the preparation of the manuscript. This dataset is not publicly accessible because: Data was not... -
Identification of vascular disruptor compounds by analysis in zebrafish embry...
In zebrafish, 161 compounds were screened and 34 were identified by visual inspection as VDCs, of which 28 were confirmed as VDCs by quantitative image analysis. Testing of the... -
Data for Turley et al. "Applying the RISK21 approach to assess predictivity o...
Data for publication Turley et al. "Applying the RISK21 approach to assess predictivity of new approach methodologies in toxicity testing and exposure assessment: a case study... -
HTTK: R Package for High-Throughput Toxicokinetics
Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") as in Pearce et al. (2017) . Chemical-specific in vitro data have been... -
ORD-017311_Data_Brown_DermPerm.xlsx
List of chemicals used for model evaluation, their MW, log KOW, and references for the original data source(s), the review(s) the data was collected from, and reference for log... -
Quantitative Structure-Use Relationship (QSUR) Model Descriptors
This data set contains ToxPrint finger prints for all chemicals in FUse that had QSAR-ready SMILES strings as well as select physicochemical properties from the Estimation... -
Functional Use Database (FUse)
There are five different files for this dataset: 1. A dataset listing the reported functional uses of chemicals (FUse) 2. All 729 ToxPrint descriptors obtained from ChemoTyper... -
High-Throughput Dietary Exposure Predictions for Chemical Migrants from Food ...
Under the ExpoCast program, United States Environmental Protection Agency (EPA) researchers have developed a high-throughput (HT) framework for estimating aggregate exposures to... -
Importance of predictor variables for models of chemical function
Importance of random forest predictors for all classification models of chemical function. This dataset is associated with the following publication: Isaacs , K., M. Goldsmith,... -
Chemical product and function dataset
Merged product weight fraction and chemical function data. This dataset is associated with the following publication: Isaacs , K., M. Goldsmith, P. Egeghy , K. Phillips, R....