NWISRL South Farm Study for Greenhouse gas Reduction through Agricultural Carbon Enhancement network in Kimberly, Idaho We report N2O emissions along with CO2 and CH4 from a silage corn (2013)–barley (2014)–alfalfa (2015) rotation under conventional tillage and sprinkler irrigation. The main study objectives were to evaluate the effectiveness of an enhanced-efficiency fertilizer (SuperU; stabilized granular urea with urease and nitrification inhibitors) to reduce N2O emissions when compared to granular urea, and determine GHG emissions from fall-applied dairy manure or composted dairy manure and spring-applied dairy manure. Nitrogen treatments were only applied during the first two years of the study. Compared to urea, SuperU plots emitted 53% less N2O during the monitoring period with corn, while no N2O emission reductions occurred in 2014 with barley. The N2O-N emission losses as a percentage of total N applied were 0.21% and 0.04% for urea and SuperU in 2013, respectively, with losses of 0.05% from both urea fertilizers in 2014. On average, N2O fluxes from fall and spring manure were statistically similar and greater than the other N treatments in 2014, and there was a lasting manure treatment effect on emissions when under alfalfa. Carbon dioxide fluxes, on average, were greatest from fall- and spring-applied manure during the first two years of study. Methane fluxes were negative on average, indicating microbial oxidation, and no differences occurred among the N treatments. Silage corn, barley grain, and alfalfa yields were statistically similar among all N treatments. This work demonstrates that SuperU can potentially reduce N2O emissions from irrigated cropping systems in the semiarid western United States while not affecting crop yields.